AlloMap Molecular Expression Testing

New from XDx – Announcing…

AlloMap molecular expression testing is now available for cardiac transplants as early as 2 months post cardiac transplant!

For cardiac transplant patients, acute cellular rejection is most worrisome in the first months post transplant. As of Monday, August 21, 2006, AlloMap molecular expression testing is available to help you monitor patients as early as 2 months post cardiac transplant. When combined with patient assessment, AlloMap testing can provide the confidence you need to rule out acute cellular rejection.

Freedom from Future Rejection

A CARGO sub-study showed that patients with scores < 20 in the first 6 months post transplant were free from ACR ≥ 3A(2R) for the next 80 days (~12 weeks)¹.

¹ Data on File

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Publications

XDx publications and abstracts presented below. If you would to like receive notification of future publications, click here to register for XDx updates.

Publications

Cardiac Transplantation
	Michael X. Pham, MD, MPH, Mario C. Deng, MD, Abdallah G. Kfoury, MD, Jeffrey J. Teuteberg, MD, Randall C. Starling, MD, MPH, and Hannah Valantine, MD. Molecular Testing for Long-term Rejection Surveillance in Heart Transplant Recipients: Design of the Invasive Monitoring Attenuation through Gene Expression (IMAGE) Trial. J Hear Lung Transplant 2007 Aug 26 (8):808-814.
	Yamani MH, Taylor DO, Haire C, Smedira N, Starling RC. Post-transplant ischemic injury is associated with up-regulated AlloMap gene expression. Clin Transplant 2007 Jul-Aug. 21(4):523-5.
	Yamani MH, Taylor DO, Rodriguez ER, et al. Transplant Vasculopathy is Associated with Increased AlloMap Gene Expression Score. J Hear Lung Transplant 2007 Apr. 26(4):403-6.
	Kenneth C. Fang, Clinical Utilities of Peripheral Blood Gene Expression Profiling in the Management of Cardiac Transplant Patients. J Immunotoxicology Volume 4, Issue 3 2007: 209-217.
	Russell Dedrick, Understanding Gene Expression Patterns in Immune-Mediated Disorders. J Immunotoxicology Volume 4, Issue 3 2007: 201-207.
	Heidecker, et al. (2007). "The use of transcriptomic biomarkers for personalized medicine." Heart Fail Rev 12:1–11.
	Starling et al. (2006). "Molecular testing in the management of cardiac transplant recipients: Initial clinical experience." J Heart Lung Transplant 25(12): 1289-1395.
	Deng et al. (2006). "Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling." Am J Transplant 6(6): 150-160.
	D. Bernstein, S. Mital, L. Addonizio, S. Hunt, M.C. Deng, H. Baron, S. Murali, D.Y. Tayama, T.M. Klingler, J.G. Wohlgemuth and S. Webber, Gene Expression Profiling of Cardiac Allograft Recipients with Mild Acute Cellular Rejection. J Hear Lung Transplant 2005 Feb 24(2):S65.
	Evans, R. W., G. E. Williams, et al. (2005). "The economic implications of noninvasive molecular testing for cardiac allograft rejection." Am J Transplant 5(6): 1553-1558.
	Marboe, C., M. Billingham, et al. (2005). "Nodular endocardial infiltrates (Quilty lesions) cause significant variability in diagnosis of ISHLT grade 2 and 3A rejection in cardiac allograft recipients." J Heart Lung Transplant 24(7S): S219-S226.
	Mehra, M. (2005). "The emergence of genomic and proteomic biomarkers in heart transplantation." J Heart Lung Transplant 24(7S): S213-S218.

Lupus
	Crow, M. K. and J. Wohlgemuth (2003). "Microarray analysis of gene expression in lupus." Arthritis Res Ther 5(6): 279-287.
	Crow, M. K., K. A. Kirou, et al. (2003). "Microarray analysis of interferon-regulated genes in SLE." Autoimmunity 36(8): 481-490.
	Kirou, K. A., C. Lee, et al. (2004). "Coordinate overexpression of interferon-alpha-induced genes in systemic lupus erythematosus." Arthritis Rheum 50(12): 3958-3967.

Abstracts

Cardiac and Lung Transplantation

HFSA ( Heart Failure Society of America) 2007

Kishan Jasti, Diane Vido, Cynthia Paul, Stephen Bailey, David Dean, Srinivas Murali. Gene Expression Profiling (AlloMap) Scores in Post Heart Transplant Patients Undergoing Prednisone Weaning. Journal of Cardiac Failure. August 2007 (Vol. 13, Issue 6, Page S121.)

ISHLT (International Society of Heart and Lung Transplantation) 2007

	K. Albright, T. Rowe, S.R. Hankins, H.J. Eisen. Novel Immunosuppressive Strategies: Using a Molecular Diagnostic Assay for Weaning of Immunosuppressive Agents.
	D. Bernstein, G. Berry, M. Billingham, C.C. Marboe, M.C. Deng, S. Mital, H. Eisen, G.E. Williams, H. Baron, T.M. Klingler, J.G. Wohlgemuth, J. Kobashigawa. Gene Expression Profiling Distinguishes Moderate to Severe from Mild Acute Cellular Rejection in Cardiac Allograft Recipients.
	A.R. Gangadin, M. Cadeiras, A. Sinha, M.P. Bayern, A.S. Oz, S. Memon, C.C. Marboe, N. Suciu-Foca, H. Baron, R. Dedrick, A. Califano, M.C. Deng. Gene Expression Profiling in Patients with Antibody Mediated Rejection.
	S. Keshavjee, G. Berry, C.C. Marboe, J.S. Wilt, E.P. Trulock, P.A. Corris, R.L. Doyle, K.R. McCurry, S.M. Arcasoy, R.D. Davis, J.G. Golden, M. Strueber, S. Sweet, P. Jaksch, A.C. Mehta, M.S. Mulligan, O.E. Pajaro, J.T. Sun, T.M. Klingler, S. Rosenberg, R.D. Dedrick, H. Wolters, K.C. Fang, M.R. Zamora. Refining the Identification of Discriminatory Genes for Rejection in Lung Transplantation: The LARGO Study.
	S. Keshavjee, K.R. McCurry, R.D. Davis, J.M. Pilewski, P.A. Corris, A. Zeevi, T.K. Waddell, S.M. Arcasoy, J.G. Golden, M. Strueber, R.L. Doyle, P. Jaksch, A.C. Mehta, M.S. Mulligan, O.E. Pajaro, M.R. Zamora, S. Sweet, R.N. Woodward, R.D. Dedrick, H. Wolters, K.C. Fang, E.P. Trulock. Effect of Induction Therapy on the Peripheral Blood Genomic Signature in the LARGO Lung Transplant Study.
	M. Macha, E.J. Molina, J. deFranco, J.P. Gaughan, D. Beltramo, J.B. Mcclurken, S. Furukawa. Allomap Test Does Not Correllate with Late Survival or Coronary Artery Vasculopathy in Heart Transplantation.
	M. Mehra, M.C. Deng, R. Starling, S. Murali, D. Pauly, P. Lal, M. Cadeiras, H. Baron, S. Rosenberg, H. Eisen. Does Induction Therapy Influence the Utility of Gene Expression Testing for Cardiac Allograft Rejection?
	M.R. Mehra, R.C. Starling, P.G. Lal, R.G. Woodward, R.L. Dedrick, S. Rosenberg. Gene Expression and Prediction of Early Cardiac Allograft Rejection: Discovery of a Gene-Based Corticosteroid Efficacy Measure.
	D.F. Pauly, J.M. Aranda, R.S. Schofield, S.J. Normann, J.A. Hill. The Daily Steroid Dose Correlates More Strongly Than the Time Since Heart Transplant with a Gene Expression Profile Assessment of Immune Activation.
	R.L. Scott, F.A. Arabia, D.E. Steidley, D.L. Kasper, P.A. DeValeria, L.A. Lanza. The Utility of Gene Expression Profiling To Facilitate Prednisone Weaning in a Diverse Population of Cardiac Transplant Recipients.
	S.M. Studer, T. Richards, W. Wu, K.R. McCurry, N. Kaminski. Gene Expression Profiles in Peripheral Blood for the Noninvasive Diagnosis of Chronic Lung Allograft Rejection.

ISHLT 2006

	Danaher et al. Probabilistic modeling of rejection in cardiac allograft patients as measured by biopsy and molecular diagnostics.
	Deng et al. Early detection of cardiac allograft vasculopathy through gene expression profiling – insights from the CARGO study.
	Eisen et al. Clinical implementation of molecular testing for the noninvasive detection of cardiac allograft rejection.
	Keshavjee et al. Immunoregulatory influences on peripheral transcriptional profiles of lung transplant recipients in the lung allograft rejection gene expression observational (LARGO) study.
	Marboe et al. Increased molecular testing scores associated with agreement among cardiac pathologists for the diagnosis of ISHLT 3A and higher rejection.
	Mehra et al. The clinical role of gene expression testing in anticipating the future development of acute cardiac allograft rejection.
	Zeevi et al. Gene expression profiles of peripheral blood cells reflect multiple molecular pathways and distinct mechanisms associated with cardiac allograft rejection.

AHA (American Heart Association) 2005

	Mital et al. Molecular testing for cardiac allograft rejection in children: a multicenter study.
	Yamani et al. Transplant vasculopathy is associated with increased allomap gene expression score.

IPTA (International Pediatric Transplant Association) 2005

Tayama et al. Use of molecular testing for cardiac allograft rejection evaluation in children: a multicenter study.

ISHLT 2005

	Bernstein et al. Gene expression profiling of cardiac allograft recipients with mild acute cellular rejection.
	Eisen et al. Longitudinal monitoring of cardiac allograft recipients using peripheral blood gene expression profiling: a retrospective observational analysis of molecular testing in 19 case studies.
	Marboe et al. Distinctive peripheral blood gene expression profiles in patients forming nodular endocardial infiltrates (Quilty lesions) following heart transplantation.
	Starling et al. The influence of corticosteroids on the alloimmune molecular signature for cardiac allograft rejection.

ACC (American College of Cardiology) 2004

Mehra et al. Graft dysfunction / BNP.

AST (American Society of Transplantation) 2004

Deng et al. CMV and gene expression in cardiac recipients, Boston.

ISHLT 2004

	Billingham. Plenary session / Pathology of cardiac transplant rejection.
	Marboe et al. Plenary session / Pathology: Quilty vs. rejection.
	Mehra et al. Plenary Session / Late-breaking clinical trial: predictive power of molecular testing for future rejection and clinical events in cardiac transplantation.
	Webber et al. Pediatrics: archive and prospective studies.

AHA 2003

Deng et al. Molecular testing of cardiac allograft recipients.

ISHLT 2003

Eisen et al. Plenary session / Gene expression profiling in cardiac transplant.