AlloMap Molecular Expression Testing

New from XDx – Announcing…

AlloMap molecular expression testing is now available for cardiac transplants as early as 2 months post cardiac transplant!

For cardiac transplant patients, acute cellular rejection is most worrisome in the first months post transplant. As of Monday, August 21, 2006, AlloMap molecular expression testing is available to help you monitor patients as early as 2 months post cardiac transplant. When combined with patient assessment, AlloMap testing can provide the confidence you need to rule out acute cellular rejection.

Freedom from Future Rejection

A CARGO sub-study showed that patients with scores < 20 in the first 6 months post transplant were free from ACR ≥ 3A(2R) for the next 80 days (~12 weeks)¹.

¹ Data on File

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	The AlloMap Testing Process
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	Terms To Know
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Terms To Know

Here are some terms relating to the science behind AlloMap testing.

	DNA: A chemical inside the nucleus of a cell that carries the genetic instructions. The DNA structure is a double stranded helix.
	Genes: The segments of DNA that determine the unique characteristics of each cell in your body
	Gene Expression: The messages sent from genes that direct the activity and function of your cells. Messages are carried by messenger RNA, a specific type of RNA.
	NPV (Negative Predictive Value): The percent likelihood that a concurrent biopsy will not show acute cellular rejection (ACR) for scores at or above the AlloMap score of interest. For example, in patients beyond 12 months post-cardiac transplant, using an AlloMap score of 34, the NPV for all scores below 34 is 99.2%. Thus, if the AlloMap test result was below 34, AlloMap testing would confirm absence of rejection 992 out of 1000 cases and miss episodes of acute cellular rejection in 8 out of 1000 cases. If 34 is used as a threshold, test results with scores below it could be deemed as "low" risk for rejection.
	Rejection: The process where your immune system fails to accept your transplanted organ as a part of your own body
	RNA: Delivers DNA’s genetic message from the nucleus to the cytoplasm where proteins are made. RNA is a chemical similar to a single strand of DNA where Uracil (U) is substituted for Thymine (T).
	White Blood Cells: The cells that fight foreign agents in the body, such as viruses and bacteria